Final steps in escort aptamer planning encompass synthetic variations of truncated aptamer
Final steps in escort aptamer planning encompass synthetic variations of truncated aptamer Further nuclease stabilization is achieved by substitution of 2?-OCH3 for 2?-OH at purine positions. As the 2?-OCH3 moiety is not compatible with current SELEX process enzymes, this alteration must occur during chemical synthesis following evolution of a specific aptamer sequence. Generally, most of …